Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp216 | Cell biology: osteoclasts and bone resorption | ECTS2013

Glycosaminoglycan sulfation is a key regulator of osteoclast biology and osteogenic bone cell signaling

Salbach-Hirsch Juliane , Tsourdi Elena , Ziegler Nicole , Hintze Vera , Scharnweber Dieter , Moller Stephanie , Schnabelrauch Matthias , Rauner Martina , Hofbauer Lorenz

In light of prolonged life expectancy, the need for biomaterials that govern bone regeneration increases. Improved bone regeneration and osseointegration can be achieved by funtionalizing implant materials. The extracellular matrix (ECM) affects differentiation of bone cells and is critical for bone regeneration. Here we assessed the role of the natural occurring bone ECM glycosaminoglycans (GAGs) hyaluronan (HA) and chondroitin sulfate (CS), and their sulfated derivatives, on...